Triamcinolone
Find information on thousands of medical conditions and prescription drugs.

Triamcinolone

Triamcinolone (trade names Kenalog®, Aristocort®, Nasacort®, Tri-Nasal®) is a synthetic corticosteroid given orally, by injection, inhalation, or as a topical cream. An injection is used in many situations where a lasting corticosteroid effect is required. This includes replacement therapy in people whose adrenal glands are not producing enough natural steroids (adrenal insufficiency) and decreasing inflammation in certain disease states. more...

Home
Diseases
Medicines
A
B
C
D
E
F
G
H
I
J
K
L
M
N
O
P
Q
R
S
T
Oxytetracycline
Phentermine
Tacrine
Tacrolimus
Tagamet
Talbutal
Talohexal
Talwin
Tambocor
Tamiflu
Tamoxifen
Tamsulosin
Tao
Tarka
Taurine
Taxol
Taxotere
Tazarotene
Tazobactam
Tazorac
Tegretol
Teicoplanin
Telmisartan
Temazepam
Temocillin
Temodar
Temodar
Temozolomide
Tenex
Teniposide
Tenoretic
Tenormin
Tenuate
Terazosin
Terbinafine
Terbutaline
Terconazole
Terfenadine
Teriparatide
Terlipressin
Tessalon
Testosterone
Tetrabenazine
Tetracaine
Tetracycline
Tetramethrin
Thalidomide
Theo-24
Theobid
Theochron
Theoclear
Theolair
Theophyl
Theophyl
Theostat 80
Theovent
Thiamine
Thiomersal
Thiopental sodium
Thioridazine
Thorazine
Thyroglobulin
Tiagabine
Tianeptine
Tiazac
Ticarcillin
Ticlopidine
Tikosyn
Tiletamine
Timolol
Timoptic
Tinidazole
Tioconazole
Tirapazamine
Tizanidine
TobraDex
Tobramycin
Tofranil
Tolazamide
Tolazoline
Tolbutamide
Tolcapone
Tolnaftate
Tolterodine
Tomoxetine
Topamax
Topicort
Topiramate
Tora
Toradol
Toremifene
Tracleer
Tramadol
Trandate
Tranexamic acid
Tranxene
Tranylcypromine
Trastuzumab
Trazodone
Trenbolone
Trental
Trest
Tretinoin
Triacetin
Triad
Triamcinolone
Triamcinolone hexacetonide
Triamterene
Triazolam
Triclabendazole
Triclosan
Tricor
Trifluoperazine
Trilafon
Trileptal
Trimetazidine
Trimethoprim
Trimipramine
Trimox
Triprolidine
Triptorelin
Tritec
Trizivir
Troglitazone
Tromantadine
Trovafloxacin
Tubocurarine chloride
Tussionex
Tylenol
Tyrosine
U
V
W
X
Y
Z

Corticosteroids such as triamcinolone decrease inflammation by acting within cells to prevent the release of certain chemicals that are important in the immune system. These chemicals are normally involved in producing immune and allergic responses, resulting in inflammation. By decreasing the release of these chemicals in a particular area, inflammation is reduced. This can help control a wide number of disease states, characterised by excessive inflammation. They include severe allergic reactions, inflammation of the lungs in asthma and inflammation of the joints in arthritis. The injection can be given as a single dose to people who suffer from hayfever and do not respond to conventional therapy. This can relieve symptoms over the entire hayfever period. Triamcinolone may also be given by injection directly into a joint to relieve inflammation and pain and increase mobility of the affected joint, in conditions such as arthritis.

Triamcinolone also decreases the numbers of white blood cells circulating in the blood. This is useful for the treatment of certain types of leukaemia, where there is an abnormally large production of certain white blood cells. It is also used to treat some autoimmune diseases, which are caused by the immune system attacking the body's own tissues.

Triamcinolone is used in much higher doses than the levels of corticosteroids produced naturally by the body, and as such, the usual actions of corticosteroids become exaggerated and can be observed as side effects of this medicine.

Different triamcinolone salts are available, including acetonide, hexacetonide and diacetate.

Read more at Wikipedia.org


[List your site here Free!]


Inhaled triamcinolone and adrenal suppression - Tips from Other Journals
From American Family Physician, 2/15/04 by Karl E. Miller

Treatment strategies for patients with asthma and chronic obstructive pulmonary disease (COPD) include the use of inhaled corticosteroids. These inhaled agents have been shown to reduce inflammation, improve symptoms, and reduce exacerbations in patients with asthma or COPD. Adverse effects of inhaled corticosteroids include adrenal suppression, accelerated bone mineral loss, easy bruisability, cataract formation, glaucoma, and oral thrush; however, these effects tend to be minimal and acceptable. Previous studies on the impact of inhaled corticosteroids on adrenal function have followed subjects for only 12 months or less, have involved patients with asthma who received oral corticosteroids for acute exacerbations, and have tended to include younger patients. None of these studies examined the impact of these medications on older adults. Eichenhorn and associates conducted a study to determine the long-term effect of inhaled corticosteroid therapy on adrenal function in patients with COPD over a three-year period.

Participants in the study were randomly assigned to receive 1,200 mcg per day (six puffs twice daily) of inhaled triamcinolone or placebo. The inclusion criteria were age between 40 and 69 years, forced expiratory volume in one second (FE[V.sub.1])/forced vital capacity (FVC) ratio of less than 0.70, and an FE[V.sub.1] of 30 to 90 percent of predicted. Serum cortisol levels were drawn before 10 a.m. at study entry. Participants then received 0.25 mg of cosyntropin intravenously or intramuscularly, with repeated determinations of cortisol levels at 30 and 60 minutes. These levels were determined again one and three years after the baseline levels were obtained.

A total of 221 patients were enrolled in the study, with 106 assigned to receive triamcinolone and 115 assigned to receive placebo. There was no significant difference in basal morning cortisol level or response to cosyntropin stimulation between the active medication and placebo groups at baseline or at year 1 or year 3.

Patients who met the criteria for good compliance with the treatment regimen had no significant changes in cortisol levels during the study compared with those receiving placebo. Adherence to the regimen was measured by weighing the used canisters to determine if the participants used six or more puffs per day. When the good-adherence group was compared with the placebo group, there was no significant difference in the various cortisol measurements between the two groups.

The authors conclude that there is no evidence that long-term use of 1,200 mcg of inhaled triamcinolone suppresses either basal or stimulated adrenal function in older patients with COPD. They add that this dosage of triamcinolone does not suppress patients' ability to develop a stress response. The authors caution that this study examined only the use of inhaled triamcinolone, and the results may not be extrapolated to other inhaled corticosteroids.

Eichenhorn MS, et al. Lack of long-term adverse adrenal effects from inhaled triamcinolone. Lung Health Study II. Chest July 2003;124:57-62.

COPYRIGHT 2004 American Academy of Family Physicians
COPYRIGHT 2004 Gale Group

Return to Triamcinolone
Home Contact Resources Exchange Links ebay