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Terfenadine

Terfenadine is an antihistamine formerly used for the treatment of allergic conditions. It was marketed under various the brand names including Seldane in the United States, Triludan in the United Kingdom, and Teldane in Australia. It was superceded by fexofenadine in the 1990s due to the risk cardiac arrhythmia.

Terfenadine is a prodrug, generally completely metabolised to the active form fexofenadine by intestinal CYP3A4. Terfenadine itself, however, has a cardiotoxic effect and may be absorbed and reach myocytes if the patient is concurrently taking a CYP3A4 inhibitor (e.g. erythromycin, grapefruit juice).

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	Photomutagenic properties of terfenadine as revealed by a stepwise photostability, phototoxicity and photomutagenicity testing approach Photomutagenic Properties of Terfenadine as Revealed by a Stepwise Photostability, Phototoxicity and Photomutagenicity Testing Approach ABSTRACT Administration ... From Photochemistry and Photobiology, 4/1/03 by Tarozzi, A

	Antihistamine poses possible safety risk - Seldane and other products made from terfenadine reportedly causes heart problems - Brief Article Patients taking drugs containing the antihistamine terfenadine--Seldane, Seldane D, and generic versions--should talk to their doctors about switching ... From FDA Consumer, 4/1/97

	Use of terfenadine with contraindicated drugs - adapted from the Journal of the American Medical Association 1996;275:1339-41 - Tips from Other Journals In 1990, the U.S. Food and Drug Administration noted risk factors for the development of serious ventricular arrhythmias in patients receiving terfenadine, ... From American Family Physician, 9/15/96

	Terfenadine effect on the bronchoconstriction, dermal response, and leukopenia induced by platelet-activating factor We have investigated the protective effect of oral terfenadine, a [H.sub.1] antagonist, on the dermal and pulmonary response, and changes of circulating ... From CHEST, 10/1/91 by Russell J. Hopp

	Duration of effect of loratadine and terfenadine administered once a day for one week on cutaneous and inhaled reactivity to histamine Study objective: The duration of action of several new nonsedative antihistamine preparations as assessed by skin and bronchial reactivity to histamine ... From CHEST, 3/1/93 by Manon Labrecque

	Heart arrhythmias from allergy drug - terfenadine, marketed as Seldane - Brief Article The Food and Drug Administration (FDA) last week asked the manufacturer of the popular prescription allergy drug terfenadine -- sold under the trade ... From Science News, 7/18/92

	Fluticasone vs. terfenadine for allergic rhinitis treatment - Archives of Internal Medicine, December 12-26, 1994 - Tips from Other Journals Allergic rhinitis may substantially reduce work performance, produce physical symptoms and exacerbate asthma. Various treatments, including the use of ... From American Family Physician, 4/1/95 by Barbara Apgar

	Risky drug interaction confirmed - terfenadine and ketoconazole prescribed together may cause fatal heart-rhythm disturbance - Brief Article Two commonly prescribed drugs, when taken together, can cause a rare type of heartbeat abnormality that may lead to a heart attack. One of the drugs ... From Science News, 4/3/93

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